VIGOR++ Workshop 2012 - New Diagnostic Tools for Bowel Diseases

Date: 7 Feb 2012

Hamilton HouseMabledon Place, WC1H 9BD, London, UK

Workshop Overview
This workshop will explore advances in the integration of clinical data and MRI image analysis, classification and visualisation within the concept of the Virtual Physiological Human. These are enabling the development of a multi-scale, personalized GI tract model-based diagnostic tool deployable on a cloud computing platform. Results aim to demonstrate accurate detection and grading of Crohn’s disease that affects 700,000 people in Europe alone.

The VIGOR++ 2012 Workshop serves as a forum for a diverse and rich mix of innovators - both technologists and clinicians. Attendees have a wide range of backgrounds representing all parts of the supply chain including: researchers in universities and hospitals; diagnostics and device companies; public health authorities; private healthcare providers; market analysts and patient groups. The Workshop is the place to exchange knowledge, share experiences, debate current issues, and meet colleagues and friends active in the field.

Reasons to Attend
Benefit from a programme featuring leading experts, focused on best practices, smart algorithms, practical tips and take-home messages that will help you improve your research and patient outcomes. In addition the Workshop will offer opportunities to learn about the:
a. latest screening protocols used for the diagnosis bowel diseases from medical professionals
b. newest algorithms designed to process efficiently and accurately multi-scale data
c. paradigm shift in GI modelling in the context of Virtual Physiological Human and prepare your strategy
d. innovative ICT systems handling medical data in real-time by attending the planned demonstrations
e. emerging portals that empower patients towards self-care

The Workshop is free to attend but by INVITATION ONLY to ensure a high quality of interaction. If you wish to apply for an invitation or have any questions, please email

09.00-09.30 Arrival, Registration, Refreshments & Networking
09.30-09.40 Welcome and Overview of the Day
                  Dr Costis Kompis, Vodera

Session 1 - Chair: Prof. Stuart Taylor, UCL
09.40-10.00 Challenges in Diagnosing Bowel Diseases
                  Prof Alastair Forbes, UCL
10.00-10.30 Vision and Architecture of VIGOR++
                  Dr Harry Hatzakis, Biotronics 3D
10.30-10.45 Assessment of Bowel Motility and Small Bowel MRI
                  Dr David Atkinson, UCL
10.45-11.00 Registration of the Endoluminal Surfaces of the Colon derived from Prone and Supine CT Colonography
Holger Roth, UCL
11.00-11.30 Break & Refreshments

Session 2 - Chair: Dr Frans Vos, TU Delft
11.30-11.45 Clinical Data Acquisition and Data Management
                  Jesica Makanyanga UCLH and Jeroen Tielbeek AMC
11.45-12.00 GI Wall Thickness Measurements
                  Robiel Naziroglu, TU Delft
12.00-12.15 Image Registration
                  Zhang Li, TU Delft
12.15-12.30 Modelling and Automatic Classification
                  Peter Schüffler, ETH Zurich
12.30-13.45 Lunch, Demonstrations & Networking
                  a) Processing GI Data (Jeroen Tielbeek AMC & Jesica Makanyanga UCLH
                  b) GI Wall Thickness Measurements (Robiel Naziroglu TU Delft)
                  c) Automatic Classification (Peter Schuffler- ETH Zurich
                  d) Visualisation (Prof Hans-Christian Hege, ZIB)
                  e) 3DNet Platform (Laurence Bourne – Biotronics 3D
                  f) Navigational Tools for Radiologists (Robert Tweedie – Blackford Analysis)

Session 3 - Chair: Prof Maria Petrou, Imperial College London
13.45-14.05 Interactive Visualisation
                  Prof Hans-Christian Hege, ZIB
14.05-14.25 GI Technology Roadmap
                   Dr Simon Aliwell, Vodera
14.25-14.45 Initiatives in the Treatment of Colorectal Disorders
                  Dr Mike Grahn, Enteric
14.45-15.00 The Patients’ Perspective
                  Chayim Bell, European Federation of Crohn's & Ulcerative Colitis Associations
15.00-15.30 The Evolution of Personalised Medicine
                  John Crawford, IBM Healthcare and Life Sciences
15.30-16.00 Open Discussion: VPH and diseases of the GI tract
16.00 Wrap up and close
16.30-17.30 VIGOR++ Advisory Board Meeting (VIGOR++ Advisory Board and Consortium only)

Delegate Pack
All presentations from the Workshop are available to download [pdf 17MB].

Profiles of Workshop Contributors
Costis Kompis is managing partner of Vodera, a company that provides professional services to ensure that science and engineering advances are successfully brought into the market to drive economic growth and benefit the general public. He has over 15 years of experience, the first part of which was devoted to research and development and the second part to innovation management and technology commercialisation. He serves on a number of advisory committees for scientific research, engineering and economic development while he has organised many international workshops and meetings across several technology areas. He has a PhD in Computer Science, an MSc in Technology and Innovation Management and an MEng in Electronic and Computer Engineering.

Alastair Forbes is professor of Gastroenterology at University College London and University College Hospital. He is Head of the Centre for Gastroenterology and Theme Leader for Research and Development. He was Medical Director of Core (the Digestive Disorders Foundation) and is now Chairman of the Education Committee of the European Society for Nutrition and Metabolism (ESPEN). He was previously consultant at St. Mark's Hospital (1992-2005), Dean of the St. Mark's Academic Institute, Honorary Secretary of the British Society of Gastroenterology, and Chairman of the British Association for Parenteral and Enteral Nutrition (2002-5). His interests lie mainly in inflammatory bowel disease and nutrition, including laboratory work on intestinal regeneration. 

Stuart Taylor
is the current Royal College of Radiologists Roentgen Professor for Research, Reader in Clinical Radiology at UCL and is only one of two UK radiologists to be awarded Higher Education Funding Council for England (HEFCE) senior lecturer status. He sits on the NCRI Colorectal Surgical Subgroup, is Research Officer for British Society of Gastrointestinal and Abdominal Radiology, and is a member of the Royal College of Radiologists Research Committee and European Society of Gastrointestinal and Abdominal Radiology CT colonography and Educations Committees. He leads the Department of Health Radiological Academic Clinical Fellows and Academic Clinical Lecturer Programme at UCLH/UCL. He currently heads the functional MRI research program at UCH and is lead for a new 3T MRI research facility. Current research interests include the use of MRI, CT and ultrasound in the prediction of histological markers of disease activity in Crohn’s disease. 

Harry Hatzakis
is co-founder and CEO of Biotronics3D whose 3DNet medical imaging platform is utilised by the VIGOR++ project. He has spent all his professional working years in medical technologies in Europe and North America, progressing from R&D through Product Management to Strategic Global Marketing of Diagnostic Imaging Solutions. He has ample experience in global markets having successfully introduced several new lines of products. Harry studied Electrical Engineering as well as Medicine in Greece and Electrical Engineering at Imperial College, London. His current main research is in the field of the management, analysis and visualisation of medical images and their interface to Electronic Health Records. 

David Atkinson is a Senior Lecturer in Magnetic Resonance Imaging within the UCL Division of Medicine. He has strong collaborations with colleagues in his previous group, the UCL Centre for Medical Image Computing. Prior to joining UCL in 2005 he was an EPSRC Advanced Research Fellow at Guy’s and St Thomas’ Hospital. His research interests include diffusion weighted MR imaging, image reconstruction, motion compensation and assessment.

Holger Ruth graduated with a degree in Electronic Engineering from the University of Applied Sciences Würzburg-Schweinfurt, Germany. His thesis research was conducted during an internship at the Fraunhofer Institute in Fürth, specialising in Computed Tomography for non-destructive testing. He subsequently gained an MSc in Vision, Image and Signal Processing at the Heriot-Watt University in Edinburgh, working on computer vision algorithms for autonomous underwater  vehicles. In 2009, he started a PhD at the Centre for Medical Image Computing at University College London under the supervision of Prof. David Hawkes. His focus lies on the non-rigid registration of images acquired during CT colonography with the aim of establishing anatomical correspondence between  colonic surfaces. This research aims to improve the diagnosis of colorectal lesions and to reduce false positives in the detection of cancer. Furthermore, he is interested in establishing a relationship between endoscopic video images and CT colonography for better guidance during colonoscopic interventions. 

Frans M. Vos
is the co-ordinator of VIGOR++. He obtained Masters Degrees in medical informatics as well as in computer science at the University of Amsterdam, The Netherlands, in 1993. He performed his graduation work at Yale University (USA). In 1998 he obtained the Ph.D. degree at the Vrije Universiteit Amsterdam and subsequently he was a research fellow with the Department of Applied Physics of Delft University of Technology. He became assistant professor with Delft University of Technology in 2003. Since 2000 he is also a staff member with the Department of Radiology at the Academic Medical Centre Amsterdam. Dr Vos is past treasurer of the Dutch Society for Pattern Recognition and Image Processing (2000-2007). Since 2007 he is a member of the education board of the Master’s program on Biomedical Engineering. His main research interests are in medical image processing and visualisation, particularly focussing on virtual colonoscopy, diffusion tensor imaging. He was able to acquire many research Grants from the Dutch Foundation for Scientific Research, Dutch Foundation for Technology and Philips Healthcare. He has been responsible for the development of many tools for CT colonography in Philips’ ViewForum workstation.

Jesica Makanyanga
qualified in medicine from the University of Zimbabwe and is now doing post-graduate training in gastroenterology and internal medicine in London.  She has an interest in inflammatory bowel disease and is doing a PhD on MR enterography in Crohn’s disease at University College London under the supervision of Professor Stuart Taylor and Professor Alastair Forbes. 

Jeroen Tielbeek
obtained scientific experience at the Hammersmith Hospital, Imperial College of London, studying sodium MRI in osteoarthritis and worked three years for the Eurotransplant foundation during his medical study. He graduated from Medical School at the Univeristy of Leiden in January 2011. He started his work as a PhD student at the department of Radiology in March 2011, under the supervision of prof. dr. Stoker and dr. Ponsioen. He is responsible for the recruitment of patients with Crohn's disease in the AMC and will deliver the MRI data to the Biotronics server.

Peter Schüffler
 gained his MSc in bioinformatics at the Saarland University and MPI Saarbrücken in Germany. He worked at the MPI on an automated workflow for the discovery and design of epigenetic cancer biomarkers (Methmarker). In 2008, he started his PhD in the machine learning laboratory at the ETH Zurich, Switzerland. Starting with the SIMBAD EU-project that investigates the hardly understood similarity based patterns in cancer tissue micro array images, his PhD involves various kinds of machine learning challenges in medical imaging and computational pathology. Further, he takes part on the VIGOR++ project. His interests are computational biomarker discovery in cancer genomics and proteomics as well as machine learning methods for medical computer vision.

Laurence Bourn
is a Senior Imaging Scientist at Biotronics3D with 14 years of industry experience in 3D medical imaging. He has worked for a variety of European start-up companies in medical imaging including Voxar, 3mensio and Medis. He has a broad range of technical skills including volume visualisation on GPU/CPU, high performance code and cloud computing. Laurence studied Mathematics at Warwick University and has done postgraduate work at Liverpool and Edinburgh computer science departments.

Hans-Christian Hege
is head of the Visualisation and Data Analysis Department at Zuse Institute Berlin (ZIB). After studying physics and mathematics, he performed research in computational physics and quantum field theory at Freie Universität Berlin (1984-1989). Then, he joined ZIB, initially as a scientific consultant for high-performance computing and then as head of the Scientific Visualisation Department, which he started in 1991. His group performs research in visual data analysis and develops visualisation software such as Amira and Biosphere3D. He is also the co-founder of Mental Images (1986), Indeed-Visual Concepts (1999) (now Visage Imaging), and Lenné3D (2005). He taught as a guest professor at Universitat Pompeu Fabra, Barcelona, and as honorary professor at the German Film School (University for Digital Media Production). His research interests include many branches in visual computing as well as applications in life sciences, natural sciences and engineering. He is a member of ACM, IEEE, Eurographics, GI, DPG and CURAC.

Maria Petrou
studied Physics at the Aristotle University of Thessaloniki, Greece, Applied Mathematics in Cambridge and she did her Ph.D. in the Institute of Astronomy in Cambridge, from where she also obtained her D.Sc. degree in Engineering. She has been the Chair of Signal Processing and the Head of the Communication and Signal Processing Group of the Electrical and Electronic Engineering Department at Imperial College London. Currently she is the Director of the Informatics and Telematic Institute, Centre of Research and Technology Hellas (ITI-CERTH, She has published more than 350 scientific papers on Astronomy, Remote Sensing, Computer Vision, Machine Learning, Colour analysis, Industrial Inspection, and Medical Signal and Image Processing. She has co-authored two books Image Processing: The Fundamentals (1/e 1999 and 2/e in 2010) Image Processing: Dealing with Texture (1/e 2006) both published by John Wiley. She is a Fellow of the Royal Academy of Engineering, the IET, and the IAPR, a senior member of the IEEE, and a Distinguished Fellow of the British Machine Vision Association.

Simon Aliwell
specialises in delivering innovation management, technology commercialisation, R&D and entrepreneur support services. He has lead teams providing innovation management services and consultancy to industry, government and academia and founded and ran a number of technology networks including the Sensors & Instrumentation KTN. Over the last 15 years he has worked extensively with companies large and small to help access technology, markets and both public and private sector finance. Simon has a PhD from Cambridge University and an MBA from London Business School.

Mike Grahn
is Director of Technology at Enteric. He is also a Senior Lecturer in Biochemistry and has been working with the Academic Surgical Unit, Royal London Hospital, since 1987.  His particular interests lie in the development and implementation of complex medical technologies in the treatment of colorectal disorders.  He also acts as a consultant to the European Commission and the UK Technology Strategy Board and has contributed to several medical publications.

Chayim Bell
is elected secretary of the European Federation of Crohn's & Ulcerative Colitis Associations (EFCCA) since 2009. He was born in Holland in 1983 and lives in Alphen aan den Rijn. He works as a teacher’s assistant and IT consultant for primary schools (pupils between 4 and 13 years). He was diagnosed with Ulcerative Colitis since he was 17 years old and got a pouch in 2002. Attended his first EFCCA Youth Meeting in 2003, Berlin. Joined the EFCCA Youth Group in 2005. Became group leader in 2007. EFCCA Dutch delegate since 2008, and deputy treasurer of the EFCCA from 2008 until 2009.

John Crawford
is jointly responsible for IBM’s Healthcare Business in Europe, the Middle East and Africa. He is a contributor to several healthcare IT industry groups, including COCIR, Continua Health Alliance, EHTEL and the Healthcare Group of Intellect. He represents IBM on the Industry Team Steering Group of epSOS, an EU project to enable cross-border digital health services. He is often invited to provide expert commentary about developments in eHealth, and has spoken at many conferences including EuroPACS, MIR, ECR, TTeC, pHealth,  World of Health IT, the BCS Healthcare Computing Conference, the Danish eHealth Observatory, and the Global eHealth Forum. He has taught a class on the evolution of eHealth at the INSEAD Business School, Fontainebleau, and he regularly provides briefings on IBM’s healthcare business and eHealth to the press and analysts.

Venue Map
Click on the map for directions to the workshop's venue. St Pancras International Railway Station is only few minutes away for continental arrivals by Eurostar.

Disclaimer: The VIGOR++ Consortium reserves the right to alter the programme and accepts no responsibility for views expressed by speakers or delegates.
The Workshop is supported by the European Community’s Seventh Framework Programme in the context of the VIGOR++ Project under grant agreement nr. 270379.